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Methamphetamine (MA) abuse is a major health challenge in this and many other countries worldwide. In addition to behavioral psychotherapy techniques, intense research is being directed toward the development of pharmacological treatments, including the use of a generic of Provigil Online or Modafinil. In this article, we take a look at some of the most recent studies conducted to assess the current and possible future treatments of MA dependence.

A Brief History of Methamphetamine Substance Use Disorder (MA SUD)

Methamphetamine is derived from amphetamine, a drug that was widely prescribed in the early 1950s as medicine for obesity, depression, and a variety of other issues. By the late 1960s, it had reached a peak of over 30 million prescriptions in the US alone. The illicit manufacture of the drug was initially endemic to California, but in the late 1980s, the user population broadened and regional distribution expanded.

Today, the scope of methamphetamine-dependent users in the US is estimated at around 1.6 million, and growing, which makes the search for effective treatments even more crucial.

Also called meth, speed, or crystal, methamphetamine is a drug that stimulates the nervous system. It can be smoked, snorted, injected, or ingested orally. MA is second only to cannabis as the most abused illicit drug on the planet.

Short and long-term health effects include cardiac arrhythmia, stroke, stomach cramps, anxiety, shaking, paranoia, and hallucinations. The drug also causes structural changes to the brain and prolonged use of high levels of MA causes dependence.

Current Treatments of MA Dependence

Psychotherapy still appears to be the mainstay of medical care, but the number of relapses with this type of MA dependence treatment is extremely high. Although there are yet to be any FDA-approved pharmacological treatments for MA SUD, according to studies, there are some drugs that show much promise in this area.

So while the effective management of MA dependence remains elusive, a number of human studies and clinical trials on MA SUD pharmacotherapy indicate that there is a great potential for the use of drugs like Modafinil in helping users reduce the intensity of withdrawal symptoms and cravings.

There is currently a great need for additional studies into more effective psychological treatments, as well as new pharmacological treatment options for methamphetamine dependence.

Future Treatments of MA Dependence

 Since studies have shown some promise in the area of pharmacological treatments like Provigil and Mitrazapine, the search for more effective and affordable treatment options has intensified significantly.

There has been massive progress in pharmacological interventions for the treatment of MA dependence as many new studies explore a variety of new pharmacological targets, ranging from antidepressants to GABA enhancers, antipsychotics, calcium channel blockers, and various stimulant-like medications, including Modafinil, which is an agent that promotes wakefulness.

As you can see, there are a lot of ongoing clinical trials that target MA use disorder. While there are some massive gaps in the current research, it seems that future treatments of methamphetamine dependence are leaning toward the use of psychostimulant medications like Modafinil to help users who are dependent on methamphetamines.


There is no doubt that psychotherapy has some benefits when it comes to helping those who are dealing with MA use disorder. However, depending on the level of drug use, many affected individuals stand to benefit a lot more from pharmacotherapy alternatives since they are more cost-effective and promise a much lower rate of relapse.

This is one of the main reasons why investigations into treatment options like Provigil and Modafinil should continue in order to come up with the most effective, safe, and affordable treatment for methamphetamine use disorder.